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Civitan International Research Center


About the UAB IDDRC

Welcome to the UAB Intellectual and Disabilities Research Center (IDDRC) web site. Formerly known as the UAB Mental Retardation Research Center, we are part of a national network of 21 IDDRCs with AUCD membership which includes 14 Centers with current P30 core grant funding from the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) and 7 Centers that use alternative funding mechanisms within the National Institutes of Health (NIH) to support projects relevant to intellectual disabilities. Eight P30 NICHD funded research centers are co-located in universities with UCEDDs or LENDs. For more information about our new research award please read the UAB news release in PDF format.

Our IDDRC includes a cadre of investigators who represent a broad range of disciplines and approaches committed to expanding the understanding of mental retardation and neuro-developmental disabilities (IDD). These investigators embrace our mission and dedication to the larger enterprise of ameliorating the profound effects of IDD. Our investigators are dedicated to elucidation of new knowledge regarding human development in health and disease; the use of appropriate model systems to uncover the principles of this development; the dissemination of these advances to others including individuals with IDD and their families, political leaders, scientists, health care providers, educators, and advocacy organizations with an interest in IDD; and the translation of fundamental advances into clinical practice. The UAB IDDRC encourages collaborative research between scientists across a broad range of disciplines and between clinical investigators and practitioners.

The recently enhanced emphasis on translational research including, the implementation of molecular genetics in early diagnosis, utilization of functional imaging to explore brain dynamics, expansion of clinical trials, use of molecular genetics in early diagnosis, and expanded clinical research has significantly increased these opportunities specifically for studies of sickle cell disease, pediatric brain tumor therapies, pediatric constraint therapy for cerebral palsy, neurofibromatosis, environmental toxicology, neonatal hypoxia/ischemic events, Alexander disease, Rett syndrome, teen parenting and child neglect, ADHD and autism spectrum disorder.

The IDDRC's administrative core facilities are located at the UAB Civitan International Research Center, which also serves as Alabama's University Center for Excellence in Developmental Disabilities (UCEDD) and it's LEND programs in coordination with the Civitan-Sparks Clinics. Through this website the UAB IDDRC provides information and resources on IDD to scientists, students at all levels, and the general public. We welcome any suggestions that can make this site more useful to you.

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Images From Our Research

Image from our research on Rett syndrome used on the cover of Learning & Memory showing live eYFP-neurons transfected with an eYFP expression vector provided by Core-C. This procedure was used to characterize the rapid effects of BDNF on dendritic spine density.

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Images from research in Core-C. Top: NeuN labeling of hippocampal slice culture. Bottom: TRPC1 (green) and NeuN (red) labeling of CA1 region (image enhanced for web display).


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Click image to go to national AUCD web site.